Randomized clinical trials (e.g., Teasdale, Segal, Williams, Ridgeway, Soulsby, & Lau, 2000; Ma & Teasdale, 2004) support the efficacy of Mindfulness-Based Cognitive Therapy for preventing depressive relapse. Unfortunately, there are scant studies of the treatment’s mechanisms of action. Teasdale and colleagues (2000) have speculated that MBCT is effective because it enhances participants’ ability to disengage …
Continue reading “Identifying the mechanisms of action in MBCT”
We proposed a longitudinal study of intensive Vipassana meditation to investigate training-related changes in cognitive control, and to explore the relationship between cognitive control and growth in emotional well-being. The proposed data collection included participants undergoing one month of intensive meditative training at Spirit Rock Meditation Center between February and March 2009, as well as …
Few randomized controlled trials have directly compared the effects of mindfulness and acceptance-based MBSR and reappraisal-based CBT in the treatment of anxiety disorders. In the current study, we propose a randomized pilot study that compares MBSR and group CBT to enable a direct assessment of training in reappraisal and mindfulness-based emotion regulatory strategies, and their …
Chronic stress and major depressive disorder are associated with accelerated cellular aging, indicated by shortened telomeres in peripheral blood mononuclear cells (PBMCs). Psychological distress is also related to greater oxidative stress, a known cause of telomere shortening. The primary aim of the proposed research is to determine whether mindfulness meditation reduces oxidative stress and increases …
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This project will investigate the feasibility, acceptability, effect sizes, and therapeutic mechanisms of a novel, mindfulness-oriented cognitive therapy (MOCT) intervention for alcohol dependence, focusing on how attentional processes impact craving. A randomized control group design will be used, with 24 adult alcohol dependent persons per group. The MOCT arm will participate in 8 weekly 2 …
We conducted a pilot study to investigate the feasibility, acceptability, and efficacy of an eight week “mindfulness-based” cognitive behavioral group therapy for chronic combat posttraumatic stress disorder (PTSD). Veterans seeking treatment at a Veterans Administration outpatient PTSD clinic (n=11) were enrolled in the study; five completed all eight sessions, three completed at least six sessions, …
In this proposal I seek to shed light on the behavioral and neural effects of mindfulness meditation training (MMT) on attention, memory, and inhibition in adults with attention deficit/hyperactive disorder (ADHD). Eligible subjects who reach criteria for ADHD as per evaluation by the Upenn center of cognitive therapy will attend an 8-week MMT course tailored …
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Receiving a diagnosis and undergoing cancer treatment is associated with high levels of emotional distress and related symptoms (e.g., anxiety, depression, and fatigue). MBSR has been consistently shown to reduce symptoms of stress and mood disturbance among cancer patients. Despite this, the question of “how” MBSR works has not been adequately addressed; it is not …
Continue reading “How does MBSR improve psychological functioning for cancer patients?”
Evidence points to the role of stress in the inception and maintenance of substance use disorders. Mindfulness training (MT) has shown promise in a number of stress-related maladies. However, no studies have compared MT to empirically-validated treatments for substance use disorders or assessed its impact on stress provocation. 36 individuals with alcohol and/or cocaine use …
Continue reading “Mindfulness training as treatment and mechanistic probe for drug addiction”
A considerable number of those who suffer from depression develop a chronic course of the disorder in which symptoms remain over prolonged periods of time and risk for suicidality is significantly increased. Once patients have entered such a course, response to established treatments is significantly reduced. The aim of the current study was to test …
