Mindfulness training is growing in its mainstream popularity. This keynote panel will discuss the promises of offering mindfulness training to cohorts across many major societal institutions such as healthcare, business, higher education and military/first responder communities. Paralleling its popular rise have been growing concerns regarding mainstream dissemination of contemplative training, including the ethical framework within which training programs are offered, teacher expertise and context familiarity, as well as potential contraindications of mindfulness practice. The panel will focus on three key questions regarding current considerations of the growing rise of mindfulness: (1) What have been the major challenges to developing, delivering and disseminating mindfulness programs in applied secular settings? (2) What is the current evidence-base regarding the effectiveness of mindfulness training when offered in applied settings? (3) What are key considerations as we move forward?