Filmed during Mind & Life Institute’s “Mind & Life XIII: Investigating the Mind: The Science and Clinical Applications of Meditation” on November 8-10, 2005.
Session Three – Clinical Research I: Meditation & Mental Health
Helen S. Mayberg, M.D.
Zindel V. Segal, Ph.D.
With the advent of MBSR and more recently, MBCT (mindfulness-based cognitive therapy), meditative practices have shown promise in the treatment of anxiety and depression.
This session will review the experimental evidence for the effectiveness of MBCT in reducing relapse rates for chronic depression, and how mindfulness might be functioning in the brain to regulate depressive cognitions, affect, and behaviors. The different elements comprising the meditation practices and approaches will be examined from the contemplative perspective, and cross-cultural issues discussed regarding content and context and how they may serve to synergistically optimize meditation-based interventions in Western and Asian settings.
MODERATOR: Jon Kabat-Zinn
B. Alan Wallace
His Holiness the 14th Dalai Lama
Jan Chozen Bays
Helen S. Mayberg
Zindel V. Segal
John D. Teasdale
Zindel Segal: Mindfulness-based cognitive therapy and the prevention of relapse in recurrent depression
The advent of effective treatments for mood disorders has provided relief for many depressed patients, yet staying well and preventing relapse are enduring challenges. The clinical application of mindfulness in this group acquaints patients with the modes of mind that often characterize mood disorders while simultaneously inviting them to develop a new relationship to these modes. Thoughts come to be seen as events in the mind, independent of their content and emotional charge. They need not be disputed, fixed or changed but can be held in a more spacious awareness. The growing empirical base for this approach suggests a 50% increase in relapse prophylaxis for previously depressed patients.
Helen Mayberg: Paths to recovery – neural substrates of cognitive and mindfulness-based interventions for the treatment of depression
Functional neuroimaging has established that both non-pharmacological and pharmacological treatments for depression both change the brain, though they change the brain in different ways. This presentation will present findings from positron emission tomography and functional magnetic resonance imaging studies of functional brain changes mediating depression remission using cognitive behavioral therapy. Differences between cognitive and pharmacological interventions will be discussed in the context of limbic-cortical network model of depression. Implications of this work for understanding the impact of mindfulness meditation as an intervention in the treatment of depression will be considered.
Zindel Segal, PhD
University of Toronto-Scarborough
Convening Faculty, Fellow, Planning Committee Member