College students are experiencing a mental health crisis, with anxiety and depression rates more than doubling between 2013 and 2021. While meditation has proven effective for improving mental health, we face a critical problem: unlike physical exercise where progress is visible, the brain and body changes from meditation practice are hidden and difficult to track. This makes it challenging to know who will benefit from meditation and when improvements will occur. We are conducting this study to identify the specific moments during an 8-week meditation program when measurable changes in brain activity, heart rhythm, and breathing patterns predict mental health improvements in university students. Using advanced monitoring equipment, we will track these biological signals alongside students’ reported anxiety, depression, and well-being during their meditation journey. This research is important because it could help us identify early warning signs of who will respond well to meditation therapy and who might need different approaches. By understanding the timing and patterns of these biological changes, we can develop more precise and effective mental health interventions specifically tailored for college students. This could ultimately help address the growing mental health crisis on university campuses by making meditation-based treatments more targeted and successful.